Howard Safran Selected Research

paclitaxel poliglumex (XYOTAX)

1/2018	PPX and Concurrent Radiation for Newly Diagnosed Glioblastoma Without MGMT Methylation: A Randomized Phase II Study: BrUOG 244.
6/2017	Longitudinal DSC-MRI for Distinguishing Tumor Recurrence From Pseudoprogression in Patients With a High-grade Glioma.
10/2014	Paclitaxel poliglumex, temozolomide, and radiation for newly diagnosed high-grade glioma: a Brown University Oncology Group Study.
2/2012	Neoadjuvant paclitaxel poliglumex, cisplatin, and radiation for esophageal cancer: a phase 2 trial.
8/2006	Paclitaxel poliglumex (PPX-Xyotax) and concurrent radiation for esophageal and gastric cancer: a phase I study.

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Howard Safran Research Topics

Disease

46	Neoplasms (Cancer) 04/2022 - 11/2002
25	Pancreatic Neoplasms (Pancreatic Cancer) 12/2021 - 07/2002
17	Adenocarcinoma 01/2022 - 07/2002
11	Disease Progression 11/2020 - 12/2005
10	Neoplasm Metastasis (Metastasis) 01/2020 - 03/2002
9	Stomach Neoplasms (Stomach Cancer) 01/2021 - 01/2003
8	Carcinoma (Carcinomatosis) 11/2017 - 03/2002
6	Nausea 01/2018 - 09/2002
5	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/2022 - 09/2006
5	Glioma (Gliomas) 01/2022 - 10/2014
5	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 01/2004
5	Diarrhea 08/2007 - 09/2002
4	Fatigue 01/2022 - 08/2007
4	Glioblastoma (Glioblastoma Multiforme) 01/2022 - 10/2014
4	Esophageal Neoplasms (Esophageal Cancer) 11/2017 - 01/2003
3	Hematologic Neoplasms (Hematological Malignancy) 12/2020 - 01/2012
3	Lung Neoplasms (Lung Cancer) 11/2020 - 01/2012
3	Infections 11/2020 - 03/2008
3	Hepatocellular Carcinoma (Hepatoma) 03/2015 - 02/2010
3	Exanthema (Rash) 02/2015 - 12/2005
3	Esophagitis 02/2012 - 01/2003
3	Dehydration (Water Stress) 12/2005 - 09/2002
2	Carcinogenesis 12/2022 - 01/2019
2	Melanoma (Melanoma, Malignant) 01/2021 - 01/2021
2	COVID-19 11/2020 - 09/2020
2	Anus Neoplasms (Anal Cancer) 01/2018 - 05/2013
2	Thrombocytopenia (Thrombopenia) 12/2017 - 01/2015
2	Neutropenia 12/2017 - 08/2005
2	Rectal Neoplasms (Rectal Cancer) 06/2017 - 01/2012
2	Liver Neoplasms (Liver Cancer) 02/2015 - 02/2010
2	Head and Neck Neoplasms (Head and Neck Cancer) 04/2014 - 04/2010
2	Pathologic Complete Response 02/2012 - 01/2012
2	Pneumonia (Pneumonitis) 01/2012 - 09/2002
2	Anorexia 04/2008 - 09/2002
2	Febrile Neutropenia 03/2008 - 08/2007
2	Vomiting 08/2005 - 01/2004
1	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated) 12/2022
1	Thrombocytopenia 3 01/2022
1	Brain Neoplasms (Brain Tumor) 01/2021

Drug/Important Bio-Agent (IBA)

19	Gemcitabine FDA Link 01/2020 - 09/2002
13	Paclitaxel (Taxol)FDA LinkGeneric 10/2017 - 07/2002
10	Fluorouracil (Carac)FDA LinkGeneric 01/2022 - 01/2003
8	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2022 - 05/2003
8	Carboplatin (JM8)FDA LinkGeneric 12/2017 - 11/2002
6	Cetuximab (Erbitux)FDA Link 11/2017 - 05/2006
6	Capecitabine (Xeloda)FDA Link 06/2017 - 08/2005
5	Proteins (Proteins, Gene)FDA Link 11/2020 - 05/2012
5	paclitaxel poliglumex (XYOTAX)IBA 01/2018 - 08/2006
5	Biomarkers (Surrogate Marker)IBA 01/2018 - 07/2002
5	RamucirumabIBA 10/2017 - 01/2014
5	Trastuzumab (Herceptin)FDA Link 02/2007 - 01/2004
4	avelumabIBA 04/2022 - 07/2017
4	Irinotecan (Camptosar)FDA LinkGeneric 01/2021 - 05/2003
4	Temozolomide (Temodar)FDA LinkGeneric 01/2021 - 10/2014
4	Aspartic Acid (Aspartate)FDA Link 01/2020 - 05/2012
4	Mixed Function Oxygenases (Monooxygenases)IBA 01/2020 - 05/2012
4	Monoclonal AntibodiesIBA 01/2018 - 07/2002
4	PlatinumIBA 07/2017 - 01/2003
3	TIC10 compoundIBA 12/2021 - 12/2020
3	Pharmaceutical PreparationsIBA 11/2020 - 01/2014
3	Immunoglobulin G (IgG)IBA 01/2019 - 01/2017
3	Cisplatin (Platino)FDA LinkGeneric 12/2017 - 02/2012
3	Biological ProductsIBA 01/2014 - 07/2002
3	Bevacizumab (Avastin)FDA Link 01/2012 - 05/2006
3	Docetaxel (Taxotere)FDA Link 09/2007 - 08/2005
3	Erlotinib Hydrochloride (CP 358,774)FDA Link 03/2007 - 12/2005
2	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 12/2022 - 01/2021
2	Glycogen Synthase (Synthase I)IBA 12/2022 - 01/2021
2	Leucovorin (Folinic Acid)FDA Link 01/2022 - 01/2012
2	130-nm albumin-bound paclitaxelIBA 01/2022 - 05/2016
2	B7-H1 AntigenIBA 01/2021 - 07/2017
2	Antiviral Agents (Antivirals)IBA 11/2020 - 09/2020
2	Peptide Hydrolases (Proteases)FDA Link 11/2020 - 09/2020
2	Interleukin-6 (Interleukin 6)IBA 11/2020 - 09/2020
2	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 11/2020 - 09/2020
2	CytokinesIBA 11/2020 - 09/2020
2	Mitomycin (Mitomycin-C)FDA LinkGeneric 01/2018 - 05/2013
2	eltrombopag FDA Link 12/2017 - 01/2015
2	ErbB Receptors (EGF Receptor)IBA 11/2017 - 03/2007
2	Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA 04/2016 - 01/2014
2	Lapatinib (GW572016)FDA Link 02/2011 - 04/2008
2	Radiation-Sensitizing AgentsIBA 01/2003 - 07/2002
1	Lomustine (CCNU)FDA Link 01/2022
1	Caspase 3 (Caspase-3)IBA 12/2021
1	Histones (Histone)IBA 01/2021
1	Insulin (Novolin)FDA Link 01/2021
1	XELOXIBA 01/2021
1	U 95666EIBA 01/2021

Therapy/Procedure

30	Therapeutics 01/2021 - 08/2003
20	Drug Therapy (Chemotherapy) 12/2022 - 11/2002
18	Radiotherapy 01/2020 - 07/2002
4	Adjuvant Chemotherapy 01/2021 - 02/2012
4	Immunotherapy 01/2018 - 05/2012
4	Chemoradiotherapy 01/2017 - 09/2009
3	Neoadjuvant Therapy 01/2021 - 01/2017
3	TP protocol 11/2017 - 01/2004
2	Combination Drug Therapy (Combination Chemotherapy) 12/2017 - 05/2016
2	Drug Tapering 01/2015 - 08/2005
1	Immunomodulation 01/2022
1	Induction Chemotherapy 01/2021